| To accurately describe cellular physiology |
OMNI |
Identifies a set of bottleneck reactions to be removed in the model, to minimize the disagreement between the model predictions and experimental data |
| SR-FBA |
Predicts gene expression and metabolic fluxes |
| TMFA |
Predicts intracellular flux distribution with thermodynamic constraints |
| To predict metabolic capability after genetic perturbation |
MOMA |
Minimizes the Euclidian distance from a wild type flux distribution under knock-out condition |
| ROOM |
Minimizes the number of significant flux changes in the knock-out mutant compared to the wild type |
| OptKnock |
Predicts gene knock-out targets through bilevel optimization framework |
| OptGene |
Predicts gene knock-out targets using genetic algorithm and constraints-based flux analysis |
| OptReg |
Determines the activation/inhibition and elimination reaction set for biochemical production |
