Table 2.

p16(INK4A) expression in HPV-positive invasive laryngeal tumors.

p16	HPV DNA genotype	Subsite	SEER stage	Histology	Grade	Gender	Age group
Positive	18	Glottis	Localized	SCC non-keratinizing	2	Male	40–49
Positive	35, 89	Glottis	Localized	SCC papillary	1	Male	40–49
Negative	16	Supraglottis	Regional	SCC non-keratinizing	2	Female	80–89
Negative	35	Glottis	Localized	SCC papillary	1	Female	70–79
Negative	39	Supraglottis	Regional	SCC keratinizing	2	Female	50–59
Negative	16, 54	Supraglottis	Regional	SCC keratinizing	3	Male	70–74
Negative	18, 33	Glottis	Distant	SCC keratinizing	2	Male	65–69
Negative	16	Supraglottis	Localized	SCC keratinizing	2	Male	65–69
Negative	11	Supraglottis	Distant	SCC NOS	3	Female	55–59
Negative	Untyped	Glottis	Localized	SCC verrucous	a	Male	65–69
Negative	16	Supraglottis	Regional	SCC keratinizing	3	Male	70–74
Negative	33	Supraglottis	Regional	SCC keratinizing	2	Female	55–59
Negative	16, 31, 33	Glottis	Localized	SCC keratinizing	2	Male	45–49
Negative	51	Supraglottis	Regional	SCC non-keratinizing	3	Male	75–79
Negative	51	Glottis	Localized	SCC keratinizing	2	Male	60–64
Negative	6	Glottis	Regional	SCC non-keratinizing	2	Female	50–54

^aTumor grade could not be ascertained based on the registry data and secondary pathologic review.