Table 1.
Baseline characteristics
Total cohort |
Subgroups by sex |
Subgroups by puberty |
||||||||
---|---|---|---|---|---|---|---|---|---|---|
n | (n = 101) | n | female (n = 47) | n | male (n = 54) | n | prepubertal (n = 43) | n | pubertal (n = 57) | |
Age, years | 101 | 10.9 (3.1) | 47 | 10.3 (2.9) | 54 | 11.4 (3.1) | 43 | 8.4 (1.9) | 57 | 12.8 (2.3) |
BA, years | 101 | 11.8 (2.1) | 47 | 10.9 (2.9) | 54 | 12.6 (2.9) | 43 | 9.6 (2.0) | 57 | 13.5 (2.5) |
BA SDS | 101 | 1.2 (1.1)* | 47 | 0.8 (1.2)* | 54 | 1.4 (1.0)* | 43 | 1.6 (1.1)* | 57 | 0.8 (1.1)* |
Caucasiana | 101 | 64 (63.4) | 47 | 27 (57.4) | 54 | 37 (68.5) | 43 | 19 (44.2) | 57 | 44 (77.2) |
Height SDS | 101 | 0.6 (1.0)* | 47 | 0.4 (1.0)* | 54 | 0.7 (1.1)* | 43 | 0.8 (1.0)* | 57 | 0.4 (1.0)* |
BMI SDS | 101 | 3.4 (0.6)* | 47 | 3.1 (0.5)* | 54 | 3.6 (0.7)* | 43 | 3.6 (0.7)* | 57 | 3.2 (0.5)* |
Fasting insulin, mU/Lb | 101 | 12 (6/18) | 47 | 11 (6/19) | 54 | 12 (7/16) | 43 | 7 (4/11) | 57 | 16 (10/26) |
HOMA-IRb | 101 | 2.1 (1.3/3.7) | 47 | 2.1 (1.3/3.9) | 54 | 2.3 (1.3/3.5) | 43 | 1.3 (0.8/2.0) | 57 | 2.4 (2.1/4.8) |
AUC insulin, mU/Lb | 94 | 305 (202/468) | 43 | 267 (186/454) | 51 | 309 (210/482) | 40 | 211 (159/397) | 53 | 362 (238/544) |
Oestradiol SDS | 50 | 0.0 (1.4) | 21 | −0.2 (1.1) | 29 | 0.1 (1.5) | − | 39 | 0.0 (1.3) | |
Testosterone SDSb | 64 | −0.6 (–1.2/0.3)* | 28 | −0.7 (–2.7/1.6) | 36 | −0.6 (–1.1/0.0)* | − | 51 | −0.7 (–1.3/0.4)* | |
DHEAS SDSb | 96 | 0.4 (0.0/1.0)* | 45 | 0.3 (–0.8/0.7) | 51 | 0.4 (0.1/1.0)* | 41 | 0.4 (–0.3/1.1) | 54 | 0.3 (0.0/0.9)* |
SHBG SDSb | 96 | −1.9 (–2.4/–1.1)* | 46 | −1.9 (–1.2/–2.2)* | 50 | −1.9 (–2.4/–1.1)* | 40 | −1.5 (–2.2/–0.7)* | 55 | −2.0 (–2.4/–1.4)* |
Androstenedione, nmol/Lb | 100 | 2.25 (1.30/3.60) | 47 | 2.40 (1.20/4.10) | 53 | 2.20 (1.30/3.30) | 42 | 1.25 (0.78/2.23) | 57 | 3.00 (2.15/4.50) |
Data are expressed as mean (standard deviation) unless otherwise stated. Data on oestradiol SDS and testosterone SDS are on the age group of ≥9 years. SDS, standard deviation score; BA, bone age; BMI, body mass index; HOMA-IR, homeostatic model assessment of insulin resistance; AUC, area under the curve; DHEAS, dehydroepiandrosterone sulphate; SHBG, sex hormone-binding globulin.
n (%).
Median (interquartile range).
SDS, p < 0.05.