Table 4.

Mortality and neurodevelopmental outcomes at 2 years' corrected age

	2004/2005	2010/2011	Unadjusted OR			Adjusted ORa			Adjusted ORb
			OR	95% CI	p	OR	95% CI	p	OR	95% CI	p
Mortality	25 (13.0)	28 (14.7)	1.13	0.68, 1.87	0.63	0.98	0.60, 1.59	0.93	0.79	0.49, 1.30	0.36
MDI less than −1 SD	25 (13.0)	12 (6.3)	0.55	0.29, 1.05	0.07	0.45	0.23, 0.90	0.02	0.47	0.24, 0.93	0.029
PDI less than −1 SD	26 (13.5)	9 (4.7)	0.39	0.19, 0.80	0.01	0.34	0.15, 0.71	0.004	0.35	0.16, 0.74	0.006
CP	8 (4.2)	6 (3.2)	0.89	0.32, 2.50	0.83	0.66	0.21, 2.01	0.48	0.86	0.26, 2.91	0.82
NDI	40 (20.8)	19 (10.0)	0.53	0.33, 0.87	0.01	0.54	0.32, 0.90	0.018	0.55	0.33, 0.93	0.024
Mortality or NDI	65 (33.9)	47 (24.7)	0.78	0.58, 1.05	0.10	0.76	0.56, 1.02	0.07	0.71	0.53, 0.97	0.03

Values are presented as n (%) unless otherwise indicated. Only infants born at ≥25 weeks’ gestational age were analyzed. MDI, Mental Development Index; PDI, Psychomotor Development Index; CP, cerebral palsy; NDI, neurodevelopmental impairment defined as having an MDI or PDI less than −1 SD, CP, or hearing or visual impairment.

^aCorrected for gestational age, small for gestational age, chorioamnionitis, outborn, singleton and Apgar score at 5 min.

^bCorrected for confounders in first adjusted analyses including intraventricular hemorrhage and necrotizing enterocolitis.