Table 3.
Parameter estimates for the optimal pharmacokinetic model for MOD-4023 in GHD children
| Parameter | Estimate | Standard error | Interindividual variabilitya |
|---|---|---|---|
| Apparent clearance, L/h | 2.20077× (KG/77)b | 0.151755 | 0.3682c |
| Apparent central compartment volume, L | 53.3394× (KG/77)b | 5.69329 | 0.4998d |
| Apparent distribution clearance, L/h | 0.0830071× (KG/77)b | 0.0277278 | 0.3682c |
| Apparent peripheral compartment volume, L | 5.29237× (KG/77)b | 1.00201 | 0.4998d |
| Absorption rate, h−1 | 0.356689 | 0.195624 | –e |
| Absorption lag, h | 1.38494 | 0.203909 | –e |
a
Calculated as square root (omega2) where omega2 is the variance of the term quantifying interindividual variability; 68% of the population lies within this range of the typical value.
b
KG is weight in kg; 77 is applied to permit comparison of the parameter estimates to values from studies in adults.
c
The same term for interindividual variability was applied to apparent clearance and apparent distributional clearance.
d
The same term for interindividual variability was applied to the 2 apparent distribution volumes.
e
Interindividual variability was not permitted for this term in the optimal model.