Table 4.
Parameter estimates for the optimal pharmacodynamic model for IGF-1 in GHD children
| Parameter | Estimate | Interindividual variabilitya |
|---|---|---|
| Decay rate, h−1 | 0.0120121 | –b |
| Age factor | 1 + 0.21863 × (AGE – 6)c | –b |
| Baseline IGF-1, ng/mL | 12.2417 × age factor | 0.3844 |
| Emax | 22.6046 | –b |
| EC50, ng/mL | 109.809 | 0.3068 |
| Power term | 1.97888 | –b |
a
Calculated as square root (omega2) where omega2 is the variance of the term quantifying interindividual variability; 68% of the population lies within this range of the typical value.
b
Interindividual variability was not permitted for this term.
c
AGE is age in years; 6 is the median value.