Table 5.
Parameter estimates for the optimal pharmacokinetic model for r-hGH in GHD children
| Parameterc | Estimate | Interindividual variabilitya |
|---|---|---|
| Apparent clearance, L/h | 25.1748× KG/77b | 0.7209 |
| Apparent distribution volume, L | 40.0608× KG/77b | 1.179 |
| Absorption rate, h−1 | 0.202311 | 0.0044722823 |
| Absorption lag, h | 0.117979 | 0.4442 |
a
Calculated as square root (omega2) where omega2 is the variance of the term quantifying interindividual variability; 68% of the population lies within this range of the typical value.
b
KG is weight in kg; 77 is applied to permit comparison of the parameter estimates to values from studies in adults.
c
Interindividual variability was not permitted for this term in the optimal model.