Figure 6.

Somatic Mutations in pHGG/DIPG

(A) Oncoprint representation of an integrated annotation of somatic mutations and DNA copy-number changes for the 30 most frequently altered genes in 326 pHGG/DIPG (n ≥ 6, frequency barplot on the right). Selected common fusion events are also shown where available. Samples are arranged in columns with genes labeled along rows. Age at diagnosis is provided below. Underneath, barplots are provided on a log₁₀ scale for numbers of copy-number aberrations and somatic mutations per case. Clinicopathological and molecular annotations are provided as bars according to the included key.

(B) Barplot of all recurrent somatic mutations across all 326 cases, in order of frequency, and colored independently by both anatomical location and histone mutation. See also Figure S6 and Table S6.