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Matrix effects (mean ± SD) of plasma and brain on analytes (n = 5)
| Concentration (ng/mL) | Matrix factor (%) | |
|---|---|---|
| Plasma | ||
| Nicotine | ||
| LQC | 9 | 80.32 ± 2.46 |
| MQC | 75 | 75.96 ± 18.97 |
| HQC | 150 | 77.37 ± 10.84 |
| Cotinine | ||
| LQC | 9 | 90.00 ± 0.30 |
| MQC | 225 | 78.47 ± 4.13 |
| HQC | 450 | 87.08 ± 11.61 |
| Brain | ||
| Nicotine | ||
| LQC | 9 | 92.61 ± 5.12 |
| MQC | 40 | 91.37 ± 9.13 |
| HQC | 80 | 90.54 ± 7.29 |
| Cotinine | ||
| LQC | 9 | 86.64 ± 2.38 |
| MQC | 40 | 89.65 ± 8.49 |
| HQC | 80 | 91.92 ± 5.16 |
