Fig. 1. Full reaction network of fibrillar self-assembly. The reactive fluxes for an aggregate of size n are shown schematically. Fluxes to and from the species directly connected to the aggregate of size n are hinted at where space permits. Elongation of aggregates of size n – 1 and fragmentation of all aggregates larger than n results in an increase in the concentration of aggregates of size n. By contrast, elongation and fragmentation of aggregates of size n, results in a decrease in their concentration. Moreover, aggregates of size n are also involved in the production of secondary nuclei which, however, leaves their concentration unchanged. Additionally, primary nuclei are produced directly from monomers (not shown). The full reaction network consists of an equivalent scheme for every single size of aggregate, all connected by elongation and fragmentation to yield a complex interconnected system.
