. Author manuscript; available in PMC: 2018 Jan 1.

Published in final edited form as: J Pharm Sci. 2016 Nov 11;106(1):331–337. doi: 10.1016/j.xphs.2016.09.033

Table 2.

Ethionamide concentration in individual components of BAL, lung and trachea tissues at various times after dose administration (Average ± standard deviation, n = 4–8).

Time/Treatment	C_max Plasma (μg/ml)	Trachea (μg/g)	BAL supernatant (μg/ml)	BAL pellet (μg/ml)	Lungs (μg/g)
Tmax
IV (0.083 h)	5.85 ± 1.61^1; ^a	2.69 ± 0.59^2; ^b	0.75 ± 0.37^3; ^b	0.04 ± 0.03^3; ^a,b	4.08 ± 0.62^2; ^a,b
Oral (0.39 h)	0.21 ± 0.07^1; ^b	0.95 ± 0.62^1; ^b	0.03 ± 0.05^2; ^b	0.00 ± 0.00^2; ^b	0.85 ± 1.04^1; ^b
ETH-PPs (insufflation) (0.083 h)	3.37 ± 0.87^{1, 2;} ^b	23.29 ± 9.88^1; ^a	9.15 ± 6.15^{2, 3;} ^a	0.47 ± 0.47^3; ^a	18.50 ± 15.72^{1, 2;} ^a
At Tmin
IV	0.00 ± 0.01	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00
Oral	0.01 ± 0.02	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00	0.05 ± 0.04
ETH-PPs	0.01 ± 0.01	0.03 ± 0.04	0.00 ± 0.00	0.01 ± 0.02	0.02 ± 0.04

Comparisons between fluids (plasma and BAL supernatant/pellet) and tissues within the same route of administration. Numeric superscripts show the relative ranks of values (starting from the highest values). When the means are not significantly different, the same numeric superscript is used.

^{a, b}

Comparisons between different routes of administration within the same fluid/tissue. When the means are not significantly different, the same letter superscript is used.