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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: J Pharm Sci. 2016 Nov 11;106(1):331–337. doi: 10.1016/j.xphs.2016.09.033

Table 3.

Pharmacokinetic parameters obtained by non-compartmental analysis after administration of the various treatments of Ethionamide by the different routes (Mean ± S.D.; n = 6–8).

Treatments
Parameter IV
(6 mg/kg)
Oral
(6 mg/kg)
ETH-PPs
(6 mg/kg)
AUC (0-t) (μg h/ml) 1.60 ± 0.391 0.21 ± 0.132 1.34 ± 0.121
CL (ml/h/kg) 3.93 ± 0.952 26.46 ± 12.811 4.40 ± 0.382
K (h−1) 1.45 ± 0.27 1.10 ± 0.55 1.77 ± 1.41
t1/2 (h) 0.49 ± 0.08 0.79 ± 0.40 0.75 ± 0.57
MRT (h) 0.41 ± 0.072 0.92 ± 0.251 0.43 ± 0.152
Cmax (μg/ml) 5.03 ± 0.901 0.19 ± 0.083 3.71 ± 0.602
Tmax (h) 0.08 ± 0.002 0.39 ± 0.211 0.08 ± 0.002
F (0-∞) 1.00 ± 0.001 0.17 ± 0.123 0.85 ± 0.072

AUC(0-t) = area under the curve, K = elimination rate constant; t1/2 = half-life; MRT = mean residence time; CL = clearance; Cmax = maximum concentration; Tmax = time to reach Cmax; F(0-∞) = bioavailability.

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Numeric superscripts show the relative ranks of values (starting from the highest values).

When the means are not significantly different, the same superscript is used.