Table 3.
Treatments | |||
---|---|---|---|
Parameter | IV (6 mg/kg) |
Oral (6 mg/kg) |
ETH-PPs (6 mg/kg) |
AUC (0-t) (μg h/ml) | 1.60 ± 0.391 | 0.21 ± 0.132 | 1.34 ± 0.121 |
CL (ml/h/kg) | 3.93 ± 0.952 | 26.46 ± 12.811 | 4.40 ± 0.382 |
K (h−1) | 1.45 ± 0.27 | 1.10 ± 0.55 | 1.77 ± 1.41 |
t1/2 (h) | 0.49 ± 0.08 | 0.79 ± 0.40 | 0.75 ± 0.57 |
MRT (h) | 0.41 ± 0.072 | 0.92 ± 0.251 | 0.43 ± 0.152 |
Cmax (μg/ml) | 5.03 ± 0.901 | 0.19 ± 0.083 | 3.71 ± 0.602 |
Tmax (h) | 0.08 ± 0.002 | 0.39 ± 0.211 | 0.08 ± 0.002 |
F (0-∞) | 1.00 ± 0.001 | 0.17 ± 0.123 | 0.85 ± 0.072 |
AUC(0-t) = area under the curve, K = elimination rate constant; t1/2 = half-life; MRT = mean residence time; CL = clearance; Cmax = maximum concentration; Tmax = time to reach Cmax; F(0-∞) = bioavailability.
Numeric superscripts show the relative ranks of values (starting from the highest values).
When the means are not significantly different, the same superscript is used.