Fig. 6.

Inactivation and recovery from inactivation of outward K⁺ currents were not modified in FGF13 KO mice. (A) Exemplar inactivation of I_to current traces elicited by 5-s conditioning pulses from a holding potential of −70 mV to voltages between −100 mV and +40 mV in 10-mV increments prior to a test potential at +50 mV (inset). Inset shows schematic of the voltage clamp protocol. (B) Summarized I_{to, fast} inactivation curves for WT, Myh6-MCM (Cre) and Fgf13 KO (KO) mice. (C) Summarized I_{k, slow} inactivation curves for WT, Cre, and KO mice (n=8, 9, and 10 for WT, Cre, and KO, N=3 mice per group). (D and E) Exemplar recovery from inactivation of I_to current traces determined from a holding potential of −70 mV, using 30-ms pulses separated by a recovery time from 10 to 150 ms at +50 mV (D) or from 300 to 3750 ms at +50 mV (E). Inset shows schematic of the voltage clamp protocol. (F) Normalized I_{to, fast} recovery vs interpulse interval for WT, Cre, and KO mice. (G) Normalized I_{k, slow} recovery vs interpulse interval for WT, Cre, and KO mice (n=7, 7, and 6 for WT, Cre, and KO, N=3 mice per group).