Table 3.
RDT sensitivity and specificity compared with microscopy and real-time PCR, stratified for home visits 1–4
| Home visit 1 | Home visit 2 | Home visit 3 | Home visit 4 | P value | |
|---|---|---|---|---|---|
| RDT vs. microscopy, n | 837 | 759 | 567 | 228 | |
| Sensitivity (95% CI) | 78.6 (62.6–88.9) | 87.0 (71.9–94.6) | 74.1 (48.1–89.8) | 82.8 (55.3–94.9) | 0.115 |
| Specificity (95% CI) | 96.4 (94.4–97.7) | 90.3 (86.9–92.9) | 91.1 (87.8–93.6) | 87.4 (80.6–92.1) | 0.000 |
| Positive predictive value % (95% CI) | 53.2 (39.2–66.7) | 36.7 (28.0–46.3) | 29.4 (20.4–40.3) | 49.0 (34.2–64.0) | 0.000 |
| Negative predictive value % (95% CI) | 98.8 (97.7–99.4) | 99.0 (97.9–99.6) | 98.6 (96.5–99.5) | 97.2 (91.3–99.1) | 0.086 |
| RDT vs. qPCR, n | 621 | NA | NA | NA | |
| Sensitivity (95% CI) | 75.7 (66.2–83.2) | NA | NA | NA | NA |
| Specificity (95% CI) | 96.6 (94.2–98.0) | NA | NA | NA | NA |
| Positive predictive value % (95% CI) | 58.3 (42.3–72.8) | NA | NA | NA | NA |
| Negative predictive value % (95% CI) | 98.4 (97.5–99.0) | NA | NA | NA | NA |
CI = confidence interval; qPCR = quantitative polymerase chain reaction. Home visits 5 and 6 not presented because of small sample sizes (N = 39 and N = 4, respectively).