Table 2.

Effect of silibinin feeding on endogenous metabolites in 22Rv1 xenograft tissues analyzed by 1H-NMR in hydrophilic extracts.

	Metabolite	Control (μmol/g)	SB200 (μmol/g)
1.	Cyclic amino acids	26.63±9.7	33.89±22.5
2.	Adenosine & Adenine	16.9±8.1	14.7±8.9
3.	Carbohydrate (Ribose)	24.8±49.3	13.4±5.3$
4.	Nucleotide	20.4±12.2	14.9±5.7
5.	Myoinositol	5.7±2.2	5.4±2.1
6.	Polyols and Sugars	161.6±55.2	162.1±57.5
7.	Glycine	4.9±1.9	4.2±1.3
8.	Taurine	20.9±5.4	18.8±6.0
9.	Total choline	6.5±2.1	5.9±2.2
10.	Total Creatine	6.9±1.9	6.4±2.1
11.	Glutathione	3.1±1.2	2.9±1.5
12.	Aspartate+Citrate+Methionine	4.4±1.8	4.5±2.2
13.	Total Glutathione	3.4±1.1	3.1±1.4
14.	Glutamine	3.2±0.8	2.9±1.2
15.	Succinate	3.8±1.5	3.6±1.8
16.	Glutamate	6.6±1.8	6.1±1.9
17.	Total CH2 and CH3	49.2 ±19.7	49.8±19.6
18.	Acetate	2.5±1.3	1.3±0.5#
19.	Arginine and Lysine	8.2±1.8	8.2±2.9
20.	Alanine	7.8±2.9	7.1±2.6
21.	Lactate	20.7±4.6	14.9±5.4#
22.	Branched chain amino acid	12.6±5.1	12.1±4.6

^#p ≤ 0.01;

^$p ≤ 0.05