TABLE 2.

CES1 genotypes, CES1 protein expression, CES1 activity on enalapril metabolism, and the activity normalized by CES1 protein expression in human livers carrying CES1 nsSNPs

Subject Number	S75N	D203E	A269S	G143E	I49V	L97I	A93V	A156T	Enalapril Hydrolysis Rate	CES1 Protein Expression	Normalized CES1 Activity
									pmol/min per mg protein	pmol/mg protein	pmol/min per pmol CES1
L2	S/N	D/D	A/A	G/G	I/I	L/L	A/A	A/A	40.3	104.17	0.39
L16	S/N	D/D	A/A	G/G	I/I	L/L	A/A	A/A	45.3	84.45	0.54
L40	S/N	D/D	A/A	G/G	I/I	L/L	A/A	A/A	93.4	170.44	0.55
L8	S/N	D/E	A/S	G/G	I/I	L/L	A/A	A/A	62.4	184.06	0.34
L31	S/N	D/E	A/S	G/G	I/I	L/L	A/A	A/A	12.6	104.39	0.12
L45	S/N	D/E	A/S	G/G	I/I	L/L	A/A	A/A	41.1	118.41	0.35
L60	S/N	D/E	A/S	G/G	I/I	L/L	A/A	A/A	64.4	194.12	0.33
L61	S/N	D/E	A/S	G/G	I/I	L/L	A/A	A/A	50.3	141.49	0.36
L72	S/N	D/E	A/S	G/G	I/I	L/L	A/A	A/A	153.7	266.06	0.58
L90	S/N	D/E	A/S	G/G	I/I	L/L	A/A	A/A	36.3	102.01	0.36
L95	S/N	D/E	A/S	G/G	I/I	L/L	A/A	A/A	87.8	215.71	0.41
L102	S/N	D/E	A/S	G/G	I/I	L/L	A/A	A/A	83.7	104.85	0.80
L99	S/S	D/E	A/S	G/G	I/I	L/L	A/A	A/A	20.2	69.99	0.29
L41	S/S	D/D	A/A	G/E	I/I	L/L	A/A	A/A	15.9	236.16	0.07
L73	S/S	D/D	A/A	G/E	I/I	L/L	A/A	A/T	22.4	96.33	0.23
L94	S/S	D/D	A/A	G/E	I/I	L/L	A/A	A/A	28.4	156.11	0.18
L103	S/S	D/D	A/A	G/E	I/I	L/L	A/A	A/A	19.9	163.28	0.12
L104	S/S	D/D	A/A	G/E	I/I	L/L	A/A	A/A	17.6	273.32	0.06
L3	S/S	D/D	A/A	G/G	I/V	L/L	A/A	A/A	0.0	155.26	0.00
L5	S/S	D/D	A/A	G/G	I/V	L/I	A/A	A/A	26.4	102.37	0.26
L89	S/S	D/D	A/A	G/G	I/I	L/L	A/V	A/A	183.6	435.68	0.42