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Oxygen consumption rate (OCR) is higher in haplogroup M than in haplogroup N. OCR values were measured in 21 cybrid cell lines after sequential treatments with oligomycin (0.1 mg/ml) and the OxPhos uncoupling agent trifluoromethoxy carbonyl cyanide phenylhydrazone (FCCP; 0.1 μM). (a, b) Comparison of basal (a) and uncoupled (b) mitochondrial respiratory activity. Values represent mean ± SEM of at least two independent replicates. ∗P ≤ 0.05.
