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. 2017 Sep 28;2017:1278436. doi: 10.1155/2017/1278436

Figure 4.

Figure 4

MicroRNAs (miRNAs) in cardiac apoptosis pathways. Arrows colored in red indicate the functions of depression; arrows colored in green indicate the functions of activation. Abbreviations for mRNAs: AIFM3: apoptosis inducing factor; Akt: protein kinase B; ALDH2: aldehyde dehydrogenase 2; Bcl-2: B-cell CLL/lymphoma 2; Bim: Bcl2 like 11; Bnip3: Bcl2/adenovirus E1B 19 kDa interacting protein 3; β1AR: adrenoceptor β 1; β2AR: adrenoceptor β 2; CaMKIIδ: calcium/calmodulin-dependent protein kinase II, δ; Chek1: checkpoint kinase 1; CypD: Cyclophilin+D; FGFR2: fibroblast growth factor receptor 2; Foxo3: Forkhead box O3; Giα2: G protein α i subunit; Hif-1α: hypoxia inducible factor 1, α subunit; Hsp60: heat shock protein 60; HSP70: heat shock protein 70; IGF-1R: insulin-like growth factor 1 receptor; IL-10: interleukin 10; mTOR: mechanistic target of rapamycin; NCX1: sodium/calcium exchanger 1; Nhe1: Na+/H+ exchanger 1; PDCD4: programmed cell death 4; PDK1: 3-phosphoinositide-dependent protein kinase-1; PKCε: protein kinase c beta1; PTEN: phosphatase and tensin homolog; Ptp1b: Protein Tyrosine Phosphatase-1B; P53: tumor protein p53; p65: tumor protein p65; Rho-A: Ras homolog family member A; ROCK1: Rho associated coiled-coil containing protein kinase 1; SIRT1: Sirtuin 1; TNFR1: tumor necrosis factor receptor superfamily member 1; TNF: tumor necrosis factor; JNK: c-Jun N-terminal kinase; SRF: serum response factor.