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. 2017 Oct 9;3(4):2055217317732802. doi: 10.1177/2055217317732802

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — Kaplan-Meier cumulative incidence curve. Time to next evidence of disease activity in patients retrospectively classified as not meeting newer diagnostic criteria for MS at baseline (i.e. newer CIS definition).

^†Next evidence of disease activity based on McDonald 2005 criteria (i.e. attack or any EDSS worsening or MRI event (defined as a new T1 Gd+ or new or enlarging T2 lesions on MRI)).

*Hazard ratio from Cox proportional hazards model with effects for treatment adjusted for the stratification factor (region); p values from two-sided Wald test.

CI: confidence interval; EDSS: Expanded Disability Status Scale; Gd+: gadolinium enhancing; HR: hazard ratio; MS: multiple sclerosis; MRI: magnetic resonance imaging.