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. Author manuscript; available in PMC: 2017 Oct 12.
Published in final edited form as: JAMA Oncol. 2017 May 1;3(5):636–651. doi: 10.1001/jamaoncol.2016.5945

Figure 3. The Association Between Genetically Increased Telomere Length and Odds of Cancer as a Function of Selected Characteristics.

Figure 3

A-D, The plotted data show how the strength of the relationship between genetically increased telomere length and cancer varies by the selected characteristic: the R2 statistic indicates how much of the variation between cancers can be explained by the selected characteristic; P values are from meta-regression models; circle sizes are proportional to the inverse of the variance of the log OR. A, Data for average lifetime number of stem cell divisions were downloaded from Tomasetti and Vogelstein.34 B-D, Data for percentage survival 5 years after diagnosis, cancer incidence and median age at diagnosis were downloaded from the Surveillance, Epidemiology, and End Results Program.33 Not all cancers had information available for the selected characteristics (hence the number of cancers varies across the subplots). Information was available for 9 cancers for tissue-specific rates of stem cell division, 13 cancers for percentage surviving 5 years after diagnosis, 17 cancers for cancer incidence, and 13 cancers for median age at diagnosis. OR indicates odds ratio; SD, standard deviation.