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. Author manuscript; available in PMC: 2017 Oct 12.
Published in final edited form as: JAMA Oncol. 2017 May 1;3(5):636–651. doi: 10.1001/jamaoncol.2016.5945

Table 1. Single-Nucleotide Polymorphisms Associated With Telomere Length.

SNP Chr Pos Gene EA OA EAFa βa SEa P Valuea Pheta No. of Studiesa Sample Sizea Discovery P Value Variance Explained, % Discovery Study
rs11125529 2 54248729 ACYP2 A C 0.16 0.065 0.012 6.06 × 10−3 0.313 6 9177 8.00 × 10−10 0.080 Codd et al21
rs6772228 3 58390292 PXK T A 0.87 0.041 0.014   .0497 0.77 6 8630 3.91 × 10−10 0.200 Pooley et al17
rs12696304 3 169763483 TERC C G 0.74 0.090 0.011 5.41 × 10−8 0.651 6 9012 4.00 × 10−14 0.319 Codd et al22
rs10936599 3 169774313 TERC C T 0.76 0.100 0.011 1.76 × 10−9 0.087 6 9190 3.00 × 10−31 0.319 Codd et al21
rs1317082 3 169779797 TERC A G 0.71 0.097 0.011 4.57 × 10−9 0.029 6 9176 1.00 × 10−8 0.319 Mangino et al18
rs10936601 3 169810661 TERC C T 0.74 0.087 0.011 8.64 × 10−8 0.433 6 9150 4.00 × 10−15 0.319 Pooley et al17
rs7675998 4 163086668 NAF1 G A 0.80 0.048 0.012   .01 0.077 6 9161 4.35 × 10−16 0.190 Codd et al21
rs2736100 5 1286401 TERT C A 0.52 0.085 0.013 2.14 × 10−5 0.54 4 5756 4.38 × 10−19 0.310 Codd et al21
rs9419958 10 103916188 OBFC1 T C 0.13 0.129 0.013 5.26 × 10−11 0.028 6 9190 9.00 × 10−11 0.171 Mangino et al18
rs9420907 10 103916707 OBFC1 C A 0.14 0.142 0.014 1.14 × 10−11 0.181 6 9190 7.00 × 10−11 0.171 Codd et al21
rs4387287 10 103918139 OBFC1 A C 0.14 0.120 0.013 1.40 × 10−9 0.044 6 8541 2.00 × 10−11 0.171 Levy et al25
rs3027234 17 8232774 CTC1 C T 0.83 0.103 0.012 2.75 × 10−8 0.266 6 9108 2.00 × 10−8 0.292 Mangino et al18
rs8105767 19 22032639 ZNF208 G A 0.25 0.064 0.011 <.001 0.412 6 9096 1.11 × 10−9 0.090 Codd et al21
rs412658 19 22176638 ZNF676 T C 0.35 0.086 0.010 1.83 × 10−8 0.568 6 9156 1.00 × 10−8 0.484 Mangino et al18
rs6028466 20 39500359 DHX35 A G 0.17 0.058 0.013   .004 0.533 6 9190 2.57 × 10−8b 0.041 Mangino et al18 and Gu et al20
rs755017 20 63790269 ZBTB46 G A 0.17 0.019 0.0129   .34 0.757 5 8026 6.71 × 10−9 0.090 Codd et al21

Abbreviations: β, standard deviation change in telomere length per copy of the effect allele; Chr, chromosome; EA, effect allele; EAF, EA frequency; OA, other allele; Phet, P value for between-study heterogeneity in association between SNP and telomere length; Pos, base-pair position (GRCh38.p3); SE, standard error; SNP, single-nucleotide polymorphism.

a

Summary data from Mangino et al.18

b

From a meta-analysis of Mangino18 and Gu20 performed in the present study.