Table 4.

Multivariate Cox Regression Analysis of Association with DRFS

Validation Cohort (N=183)*
Factor	Hazard Ratio	95% CI	P value
Age (>50 vs ≤50)	0.53	0.27 – 1.03	0.062
Clinical Nodal Status (pos vs neg)	1.76	0.84 – 3.67	0.134
Clinical Tumor Stage (T3 or T4 vs T1 or T2)	2.13	1.13 – 4.02	0.020
Histologic Grade (3 vs 1 or 2)	0.64	0.32 – 1.28	0.206
ER Status (IHC positive vs negative)	0.34	0.18 – 0.65	0.001
Taxane (docetaxel vs paclitaxel)	0.92	0.49 – 1.73	0.796
Prediction (Rx Sensitive vs Insensitive)	0.19	0.07 – 0.55	0.002

^*Fifteen cases were excluded from the multivariate analysis due to incomplete data. Likelihood ratio test for the addition of Genomic Prediction to the model was 13.8 on one degree of freedom, p = 0.0002.

The Hazard Ratio is a measure of the risk of distant relapse or death; vs, versus; ER, estrogen receptor.