Table 1.
Description of the study population
| Water‐maze | Open field | |||||
|---|---|---|---|---|---|---|
| Type of study | Female | Male | Studies | Female | Male | Studies |
| GM mouse models with mutations affecting | ||||||
| βAPP and other proteins related to dementia (gain and loss of function) | 660 | 732 | 32 | 719 | 700 | 33 |
| Prion protein (loss of function) | 143 | 144 | 4 | 164 | 121 | 5 |
| Kinases, calcium‐binding proteins, guanine nucleotide exchange factors | 358 | 320 | 19 | 289 | 261 | 15 |
| N‐CAM and related proteins, ephrins and receptors | 208 | 192 | 12 | 180 | 171 | 9 |
| Glutamate and GABA receptors; transmitter synthesis, release, uptake | 136 | 113 | 8 | 66 | 68 | 4 |
| Glucocorticoid receptors, growth factors and receptors (BDNF, CNTF, VEGF) | 224 | 201 | 10 | 260 | 257 | 9 |
| Extracellular proteases and their inhibitors | 287 | 308 | 12 | 265 | 297 | 10 |
| Circadian clock, cytoskeleton, metabolis, ribosomal proteins | 233 | 251 | 13 | 198 | 228 | 12 |
| Other studies | ||||||
| Lesions, toxicological studies, hypoxia | 131 | 136 | 6 | 76 | 87 | 4 |
| Lab strains, crosses, selective breeding | 278 | 256 | 9 | 86 | 61 | 3 |
| Total N | 2,658 | 2,653 | 125 | 2,303 | 2,251 | 104 |
| Median N per study | 17 | 17 | 18.5 | 18 | ||