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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Biochim Biophys Acta. 2017 Mar 28;1868(1):167–175. doi: 10.1016/j.bbcan.2017.03.009

Figure 3. Ral-MAP pathway interactions.

Figure 3

Stress causes activation of Ral to Ral GTP and the formation of LOOH from membrane lipids. This causes dissociation of the RLIP76 (RalBP1)/Hsf1/Hsp90/Tubulin complex, releasing Hsf1 for translocation to the nucleus in a complex with p53. RLIP76 translocates to the cell membrane, where it binds to clathrin adaptors and links its ATPase coupled GS-HNE transport with clathrin-dependent endocytosis. EGF-EGFR or IGF-IGFR complex is endocytosed and, subsequently, downstream kinase regulation is activated leading to p53 and cMyc regulation. LOOH is metabolized to 4HNE by p450, then to GS-HNE by GST. GS-HNE is transported out by RLIP76.