Table 1.

Association signals under different proportions of causal rare variants in embedded (affected) promoters.

Proportion of causal rare variants	Association signal of all affected promoters		Individual promoters identified for association
	No. of affected promoters	Association signal (R2, P value)	No. of positives	No. (%) of true positives
1	44	0.240, 7.52 × 10−152	31	28 (63.6)
0.9	45	0.234, 7.37 × 10−148	24	23 (55.1)
0.8	53	0.225, 6.57 × 10−141	21	21 (39.6)
0.7	61	0.209, 1.35 × 10−129	25	22 (36.1)
0.6	69	0.183, 2.46 × 10−112	10	9 (13.0)
0.5	84	0.168, 4.38 × 10−102	9	9 (10.7)
0.4	111	0.140, 3.55 × 10−84	2	2 (1.8)
0.3	143	0.098, 6.04 × 10−58	0	0 (0)
0.2	225	0.054, 3.69 × 10−32	0	0 (0)
0.1	497	0.015, 6.23 × 10−10	1	0 (0)