Table 1.
Selected medications and their ATS scores.
| Medication | Drug class | Muscarinic receptors |
Total ATS | ACB5 | ARS6 | ||||
|---|---|---|---|---|---|---|---|---|---|
| M1 | M2 | M3 | M4 | M5 | |||||
| Amitriptyline | Antidepressants | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 5.00 | 3 | 3 |
| Imipramine | Antidepressants | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 5.00 | 3 | 3 |
| Brompheniramine | Antihistamines | 0.75 | 0.43 | 0.43 | 0.75 | 0.75 | 3.11 | 3 | NA |
| Carbinoxamine | Antihistamines | 0.65 | 0.65 | 0.65 | 0.65 | 0.65 | 3.25 | 3 | NA |
| Chlorpheniramine | Antihistamines | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 5.00 | 3 | 3 |
| Diphenhydramine | Antihistamines | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 5.00 | 3 | 3 |
| Benztropine | Anti-Parkinson agents | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 5.00 | 3 | 3 |
| Trihexyphenidyl | Anti-Parkinson agents | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 5.00 | 3 | NA |
| Chlorpromazine | Antipsychotics | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 5.00 | 3 | 3 |
| Haloperidol | Antipsychotics | 1.00 | 0.39 | 0.39 | 1.00 | 1.00 | 3.78 | 1 | 1 |
| Perphenazine | Antipsychotics | 0.78 | 0.78 | 0.78 | 0.78 | 0.78 | 3.90 | 3 | 3 |
| Risperidone | Antipsychotics | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 5.00 | 1 | 1 |
| Thioridazine | Antipsychotics | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 5.00 | 3 | 3 |
| Trifluoperazine | Antipsychotics | 0.81 | 0.70 | 0.81 | 0.81 | 0.70 | 3.83 | 3 | 3 |
| Alprazolam | Benzodiazepines | 0.00 | 0.00 | 0.00 | 0.30 | 0.30 | 0.60 | 1 | NA |
| Clorazepate | Benzodiazepines | 0.34 | 0.34 | 0.34 | 0.34 | 0.34 | 1.70 | 1 | NA |
| Diazepam | Benzodiazepines | 0.40 | 0.40 | 0.40 | 0.40 | 0.40 | 2.00 | 1 | NA |
| Atropine | Gastrointestinal agents | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 5.00 | 3 | 3 |
| Dicyclomine | Gastrointestinal agents | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 5.00 | 3 | 3 |
| Hyoscyamine | Gastrointestinal agents | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 5.00 | 3 | 3 |
| Loperamide | Gastrointestinal agents | 0.49 | 0.49 | 0.49 | 0.49 | 0.49 | 2.45 | 1 | 2 |
| Promethazine | Gastrointestinal agents | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 5.00 | 3 | 3 |
| Ranitidine | Gastrointestinal agents | 0.65 | 0.65 | 0.00 | 0.00 | 0.00 | 1.30 | 1 | 1 |
| Orphenadrine | Muscle relaxants | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 5.00 | 3 | NA |
| Fentanyl | Opioids | 0.39 | 0.42 | 0.42 | 0.38 | 0.38 | 1.99 | 1 | NA |
ACB, anticholinergic cognitive burden; ARS, anticholinergic risk scale; ATS, anticholinergic toxicity score; NA, not available.