Table 3.

AC-related ADEs and ATS scores by medication.

	Number of exposed patients	Percent of exposed patients	Number of all ADEsb	ADE incidence rate (per patient)	Number of tachycardiab	Tachycardia incidence rate (per 100 patients)
Promethazine	103,960	36.15	7148	0.07	319	0.31
Chlorpheniramine	42,277	14.70	2268	0.05	42	0.10
Alprazolama	36,969	12.85	5292	0.14	399	1.08
Diazepama	29,615	10.3	2112	0.07	124	0.42
Ranitidine	17,962	6.25	2977	0.17	162	0.90
Brompheniramine	17,238	5.99	1030	0.06	24	0.14
Amitriptyline	10,357	3.60	2706	0.26	204	1.97
Atropine	10,334	3.59	1140	0.11	43	0.42
Dicyclomine	9499	3.30	1252	0.13	48	0.51
Hyoscyamine	8566	2.98	1044	0.12	41	0.48
Diphenhydramine	5956	2.07	481	0.08	16	0.27
Orphenadrine	4316	1.50	308	0.07	15	0.36
Risperidonea	2854	0.99	626	0.22	42	1.46
Carbinoxamine	1803	0.63	89	0.05	2	0.10
Fentanyl	1646	0.57	828	0.50	54	3.29
Imipramine	1280	0.45	290	0.23	15	1.16
Loperamide	1078	0.37	190	0.18	11	1.05
Clorazepatea	735	0.26	112	0.15	10	1.30
Benztropine	322	0.11	159	0.49	12	3.88
Chlorpromazinea	272	0.09	60	0.22	5	1.97
Haloperidola	203	0.07	82	0.40	8	3.81
Trihexyphenidyl	118	0.04	52	0.44	3	2.52
Perphenazinea	76	0.03	27	0.36	3	3.91
Thioridazinea	24	0.01	7	0.30	1	2.48
Trifluoperazinea	19	0.01	14	0.76	1	3.13

^aAgitation, irritability, and hallucinations were not included as eligible ADEs if a patient had any fills for antipsychotics or benzodiazepines.

^bAdjusted using baseline ADEs in the unexposed cohort.

ADE, adverse drug event; ATS, anticholinergic toxicity score.