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Representative images of well-differentiated (a), moderately-differentiated (b) and poorly-differentiated HCC (c) in liver biopsy tissue. In the HCC samples with better differentiation, the proportion of cells with high expression of P1-HNF4α is significantly higher than P2-HNF4α, whereas in HCC samples with poor differentiation, P2-HNF4α expression was more common.
HCC, hepatocellular carcinoma; HNF4α, hepatocyte nuclear factor 4 alpha; P1, promoter 1; P2, promoter 2.
