Table 3.
Univariate and multivariate analyses of prognostic variables for overall survival.
| Variables | Univariate analysis |
Multivariate analysis |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p | HR | 95% CI | p | |
| Age, years | 0.998 | 0.991–1.005 | 0.620 | |||
| Sex | 1.018 | 0.765–1.354 | 0.904 | |||
| HBsAg | 1.052 | 0.833–1.329 | 0.672 | |||
| AFP | 1.679 | 1.383–2.037 | <0.001 | 1.471 | 1.207–1.792 | <0.001 |
| Cirrhosis | 0.952 | 0.764–1.187 | 0.662 | |||
| Tumour size, cm | 1.761 | 1.433–2.163 | <0.001 | 1.641 | 1.332–2.021 | <0.001 |
| Tumour multiplicity | 1.169 | 0.988–1.384 | 0.069 | |||
| Differentiation | 1.199 | 1.005–1.430 | 0.043 | |||
| TNM | 1.504 | 1.273–1.777 | <0.001 | |||
| Vascular invasion | 2.087 | 1.696–2.567 | <0.001 | 1.795 | 1.453–2.218 | <0.001 |
| Involucrum | 1.038 | 0.876–1.230 | 0.665 | |||
| P2-HNF4α | 1.408 | 1.165–1.701 | <0.001 | 1.385 | 1.145–1.675 | 0.001 |
AFP: α-fetoprotein; CI, confidence interval; HBsAg: hepatitis B virus surface antigen; HNF4α, hepatocyte nuclear factor 4 alpha; HR, hazard ratio; P2, promoter 2.