Fig 1. Example uses of diffusion.

a. Diffusion of heat from a single query gene in the upper left, denoted with a green diamond, demonstrates that heat diffusion recapitulates network distance to the query set. b. A local network hypothesis for Vemurafenib resistance in cell line LOX-IMVI, correcting for a responsive cell line, A375. LOX-IMVI mutated genes appear outlined in red. The original Vemurafenib query genes appear as green diamonds. Three interaction types are present in this network: Grey dotted lines are protein-protein binding interactions, green arrows indicate control of localization, and blue arrows indicate phosphorylation.