Table 4. Association between constant or decreased (versus increased) inflammatory parameters within 12 weeks and baseline values/changes in frailty score, handgrip strength, and physical performance.
| Constant or decreased | ||||||||
|---|---|---|---|---|---|---|---|---|
| TNF-α | Log-IL-6 | Log-CRP | Leukocytes total | |||||
| OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value | |
| BL frailty status (SHARE-FI score) | 0.79 (0.43–1.46) | 0.447 | 1.18 (0.66–2.09) | 0.570 | 0.62 (0.30–1.27) | 0.194 | 1.14 (0.65–2.01) | 0.642 |
| BL handgrip strength (kg/m2) | 0.94 (0.83–1.05) | 0.265 | 0.99 (0.89–1.09) | 0.801 | 1.00 (0.88–1.14) | 0.978 | 0.97 (0.88–1.08) | 0.591 |
| BL physical performance (SPPB score) | 1.09 (0.85–1.39) | 0.495 | 0.96 (0.77–1.20) | 0.720 | 1.16 (0.90–1.51) | 0.262 | 0.97 (0.78–1.21) | 0.798 |
| Δ frailty status (SHARE-FI score) | ||||||||
| Constant or decreased | 1.75 (0.45–6.79) | 0.418 | 1.30 (0.40–4.29) | 0.663 | 2.47 (0.56–10.93) | 0.233 | 0.95 (0.29–3.11) | 0.929 |
| Increased | 1 | 1 | 1 | 1 | ||||
| Δ handgrip strength (kg/m2) | ||||||||
| Constant or decreased | 1 | 1 | 1 | 1 | ||||
| Increased | 0.52 (0.15–1.84) | 0.307 | 1.29 (0.42–3.93) | 0.658 | 0.66 (0.17–2.51) | 0.541 | 0.63 (0.21–1.93) | 0.421 |
| Δ physical performance (SPPB score) | ||||||||
| Constant or decreased | 1 | 1 | 1 | 1 | ||||
| Increased | 0.56 (0.16–2.03) | 0.378 | 4.54 (1.33–15.45) | 0.016 | 0.49 (0.13–1.87) | 0.294 | 1.37 (0.45–4.22) | 0.582 |
Values are based on univariate logistic regression analyses, with constant or decreased inflammatory parameters (≤0.00 units) as dependent variables, adjusted for sex, age, anti-inflammatory medication, chronic rheumatism, and group. Odds ratio (OR) and 95% confidence interval (95% CI) are presented. BL = baseline; SHARE-FI = Frailty Instrument of the Survey of Health, Ageing and Retirement in Europe; SPPB = Short Physical Performance Battery, Δ = changes from baseline to 12 weeks.