Skip to main content
. 2017 Oct 12;12(10):e0186035. doi: 10.1371/journal.pone.0186035

Fig 1. Survival and analysis of human cell engraftment and lineage distribution in PB of transplanted NSGS mice.

Fig 1

NSGS mice transplanted with control cells (MIG mice) and BCR-ABL1 expressing cells (BA mice) were sacrificed at signs of illness and survival time is shown in (A). Red blood cells (RBC) measured in PB is shown in (B). The spleen weights of mice at time of sacrificed is shown in (C). Untreated NSGS mice 12–15 weeks of age are used as control for spleen weights. Platelet (Plt) counts (D), white blood cell (WBC) count (E), level of human CD45+GFP- (F) and CD45+GFP+ (G) and the level of human CD33+ myeloid cells (H and I) was measured in PB at 4, 8 and 12 weeks post transplantation. GraphPad Prism Version 6.0a was used to perform Student’s t-test (unpaired, two-tailed) for statistical analysis and variation is shown as standard deviation. P-values ≤ 0.05 were considered statistically significant. Log-rank (Mantle-Cox) test was used for survival differences.