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. 2017 Oct 12;12(10):e0186071. doi: 10.1371/journal.pone.0186071

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© 2017 Muncy et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — OASIS data are first converted into structural NIfTI (ORIG) and MGZ files. MGZ files are processed via FreeSurfer (FS). NIfTI files are rotated (RROT) which are then N4-bias corrected (N4BC). Also, RROT files are skull-stripped (N4SS; which has its own bias correction step). The output of each pipeline step is registered with a segmented template, and ROI masks are warped from template to participant pipeline-step space. ROI volumes are then extracted from the segmentation masks. FreeSurfer pre-processing is entirely self-contained, and produced its own set of ROI volumes.