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. 2017 Oct 12;12(10):e0186116. doi: 10.1371/journal.pone.0186116

Fig 6. Conceptual hypothesis.

Fig 6

A. Inter-endothelial gap junction is fully functional due to intact GCX (green arrows show Lucifer Yellow dye flux) in control conditions, when cells self-recover HS, or when HS is artificially recovered by treatment of cells with combination of exogenous HS and S1P. B. Degraded HS from GCX will cause the dislocation of Cx43 and malfunction of gap junction channels thereby preventing the movement of Lucifer Yellow dye across inter-endothelial gap junctions (red line indicates the improper functioning or blockage of gap junctions). C. Treatment of enzyme-treated cells with exogenous HS or S1P does not fully reset CX43 and/or recover intercellular gap junctional communication.