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Up-regulation of LYAR by Myc protects cancer cells against apoptosis through reducing CHAC1 gene expression. Myc oncoproteins directly up-regulate LYAR expression by activating its gene transcription. LYAR interacts with PRMT5 and thereby suppresses CHAC1 gene transcription, leading to reactive oxygen species reduction, cancer cell survival and tumourigenesis. The PRMT5 inhibitor GSK3326595 is likely to block LYAR-mediated cell survival.
