Table 1.

Characterization of the 36 adult MID patients included in this study

Patients	Age (years)	Sex	BCD	Mutation	NAO	NAAO	NOIPH	MIMODSs
1	57	M	nd	tRNA(Leu)	7	13	23	43
2	66	M	n	ND1	7	16	26	49
3	65	F	C1,2,3	nd	6	14	25	45
4	79	M	C1-4	nd	7	14	20	41
5	81	F	C4	nd	3	4	8	15
6	71	M	nd	tRNA(Thr)	3	6	12	21
7	46	M	C1-4	nd	5	11	23	39
8	51	M	C4	nd	4	10	15	29
9	34	F	C1-4	nd	8	12	20	40
10	81	F	C2,3	nd	5	12	24	41
11	70	F	n	mtDNAdel	8	14	23	45
12	38	F	nd	tRNA(Glu)	4	8	13	25
13	75	F	C1	ND1	7	19	33	59
14	66	F	nd	16S-rRNA	3	7	17	27
15	74	M	C1	nd	5	11	15	31
16	29	F	nd	mtDNAdel	9	20	44	53
17	59	M	C1	nd	4	6	12	22
18	56	M	nd	ND1	4	12	23	39
19	43	M	nd	cytb, ND1	9	21	41	71
20	64	M	nd	tRNA(Lys)	6	10	22	38
21	45	F	nd	mtDNAdel	4	5	10	19
22	82	F	C1	nd	7	16	29	52
23	73	F	nd	tRNA(Lys)	7	15	32	54
24	62	M	C2,3	nd	6	11	14	31
25	47	M	nd	ND3	3	8	11	22
26	50	M	C4	nd	7	10	21	38
27	82	F	nd	cytb	5	10	17	32
28	68	F	nd	tRNA(Lys)	4	11	19	33
29	44	M	nd	tRNA(Lys)	1	1	1	3
30	60	M	nd	ND3	2	3	6	11
31	65	F	nd	tRNA(Iso), cytb, ATP6	8	18	31	57
32	68	M	C1	nd	4	6	14	24
33	53	M	nd	ND1	4	7	15	26
34	49	F	C1-4	mtDNA depletion	4	7	10	21
35	67	F	C1	nd	7	10	18	35
36	67	M	C2,3,4	nd	5	11	21	37

Note: Gene names are in italics.

Abbreviations: BCD, biochemical defect; C, respiratory chain complex; F, female; M, male; MID, mitochondrial disorder; MIMODSs, mitochondrial multiorgan disorder syndrome score; n, normal; NAAO, number of abnormalities in all organs; NAO, number of affected organs; nd, not done; NOIPH, number of individual PubMed hits.