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. 2017 Oct 15;28(21):2887–2903. doi: 10.1091/mbc.E17-01-0082

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© 2017 Bondu et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 7: — Binding of SNV to integrin PSI induces integrin activation. (A) Force histogram of low affinity α_IIbβ₃-^RGDP2Y₂R interactions; (the loading rate, r_f, was 720 pN/s; N refers to the total number of adhesion events for all histograms). (B) Force histogram of α_IIbβ₃-^RGDP2Y₂R interactions in the presence of 2 mM Mn²⁺ (r_f = 700 pN/s). (C) Fluorescence micrographs (bottom view) of an integrin-functionalized cantilever preincubated with fluorescently labeled SNV^R18. (D) Force histogram of α_IIbβ₃-^RGDP2Y₂R interactions with SNV bound to the integrin PSI domain (r_f = 739 pN/s). (E) Fluorescence micrographs (bottom view) of an integrin-functionalized cantilever preincubated with fluorescently labeled SNV^R18 and PSI domain polypeptide for blocking SNV binding. (F) Force histogram of integrin after probe was exposed to SNV^R18 and PSI domain peptide. (G) SNV functionalized cantilever. (H) Force histogram of SNV–α_IIbβ₃ interactions in CHO-A24 cells.