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A) Topologically Associating Domains (TADs).
B) (Top) High resolution Hi-C in Rowley et al reveals small compartmental domains at the boundaries of some TADs in Drosophila. (Bottom) Molecular underpinnings of TAD boundaries: cohesin associated CTCF-CTCF loops, and gene-gene interactions.
C) Model of genome structuring through phase separation of transcriptional activators and repressors.
