Table 2.
Temporal trends in the incidence of HCV-related outcomes among veterans with hepatitis C virus infection by gender
| Outcome | Men | Women | ||||
|---|---|---|---|---|---|---|
| APC % (95% CI)+ | AAPC % (95% CI)+ | Segment | APC % (95% CI)+ | AAPC% (95% CI)+ | P-value* | |
| Cirrhosis | ||||||
| Year 1–3 | 43.4 (24.3–65.3) | 13.1 (11.4–14.9) | Year 1–3 | 51.5 (27.8–79.7) | 15.2 (12.8–17.6) | 0.99 |
| Year 3–6 | 15.8 (12.3–19.3) | Year 3–7 | 16.4 (13.9–19.0) | |||
| Year 6–10 | 8.6 (7.3–9.9) | Year 7–15 | 6.9 (6.3–7.6) | |||
| Year 10–15 | 4.8 (3.8–5.8) | ---- | ---- | |||
| Decompensated cirrhosis | ||||||
| Year 1–3 | 52.2 (27.1–82.3) | 15.6 (13.0–18.2) | Year 1–3 | 53.7 (24.6–89.6) | 16.9 (13.9–19.9) | 0.97 |
| Year 3–7 | 17.1 (15.0–19.3) | Year 3–7 | 19.0 (16.2–21.9) | |||
| Year 7–15 | 7.2 (6.2–8.2) | Year 7–15 | 8.1 (7.1–9.2) | |||
| Hepatocellular cancer | ||||||
| Year 1–3 | 63.4 (37.0–95.0) | 21.0 (18.6–23.4) | Year 1–5 | 47.3 (36.3–59.3) | 25.3 (22.5–28.1) | 0.72 |
| Year 3–6 | 25.2 (20.1–30.4) | Year 5–15 | 17.4 (15.4–19.4) | |||
| Year 6–10 | 15.9 (13.8–18.0) | ---- | ---- | |||
| Year 10–15 | 8.7 (6.8–10.6) | ---- | ---- | |||
APC – Annual percent change
AAPC – Average annual percent change
CI – confidence interval
+
All p-values are <0.01 indicating there is a significant change over time for each segment
*
P-value for test for parallelism comparing males vs. females