Table 4.

Vascular disease adjusted associations of LVM with neuroimaging and neurocognitive findings (per 25gm difference of LVM)

	Basic adjustment			Full adjustment
Neuroimaging findings
	Coefficient	95% CI	p	Coefficient	95% CI	p
Brain volume (%)	−0.288	(−0.620, 0.044)	0.089	−0.324	(−0.660, 0.012)	0.059
Hippocampal volume (%)	−0.009	(−0.015, −0.003)	0.002 *	−0.010	(−0.016, −0.004)	0.001 *
White matter grade	0.102	(0.026, 0.178)	0.008 *	0.098	(0.020, 0.177)	0.013 *
White matter hyperintensity volume (%)	0.028	(−0.005, 0.062)	0.097	0.026	(−0.009, 0.061)	0.152
	Odds ratio	95% CI	p	Odds ratio	95% CI	p
Infarcts	1.131	(0.969, 1.321)	0.119	1.114	(0.950, 1.306)	0.185
Hemorrhage	0.767	(0.498, 1.179)	0.227	0.754	(0.481, 1.184)	0.221
Neurocognitive findings
	Coefficient	95% CI	p	Coefficient	95% CI	p
3MSE	−0.620	(−1.110, −0.131)	0.013 *	−0.565	(−1.063, −0.067)	0.026
WAIS-IV Coding	−0.328	(−1.130, 0.475)	0.424	−0.208	(−1.037, 0.621)	0.622
COWA	−0.760	(−1.465, −0.055)	0.035	−0.685	(−1.403, 0.033)	0.061
CVLT-II Learning	−0.034	(−0.341, 0.272)	0.827	−0.038	(−0.355, 0.279)	0.815
CVLT-II Short recall	−0.063	(−0.200, 0.075)	0.371	−0.075	(−0.216, 0.066)	0.300
CVLT-II Long recall	0.001	(−0.146, 0.147)	0.991	0.000	(−0.151, 0.151)	0.998

Basic models adjust for age, sex, education, income, site, BMI, ApoE ε4 allele carrier status, duration of follow-up and vascular disease at follow-up.

Full models adjust additionally for smoking, alcohol use, PSS, prior atrial fibrillation, diabetes, and hypertension.

95% CI, 95% confidence interval; p, p-value (unadjusted for multiple comparisons)

Statistical significant results are indicated by * and are corrected for multiple comparisons using the Benjamini Hochberg procedure to obtain a false discovery rate of 0.10.

3MSE, Modified Mini-Mental State Examination

WAIS-IV, Wechsler Adult Intelligence Scale Fourth Edition

COWA, Controlled Oral Word Association Test

CVLT-II, California Verbal Learning Test-II Short Form