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. 2017 Oct 12;7:13089. doi: 10.1038/s41598-017-13283-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mediation pathway in the association between hepatitis B virus (HBV) infection and any cataract through aspartate aminotransferase (AST). (A) Total effect (path c) of HBV infection on cataract, (B) Direct (path c’) and indirect (path a × path b) effects of HBV infection on any cataract through high AST (>49.9 IU/L). Path a indicates the direct effect of HBV infection on high AST. Path b indicates the direct effect of high AST on any cataract. Goodness of fit measures for all mediation models were: the model’s relative χ² = 1.63 with P value = 0.133, RMSEA = 0.008, and CFI = 0.998. Direct, indirect, and total effects and percent mediated are also shown in Table 2.