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. 2017 Oct 12;7:13026. doi: 10.1038/s41598-017-13432-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Islet hypertrophy in response to high-fat high-sucrose (HFHS) diet was attenuated in TFG^loxP/loxP; MIP-Cre mice. (a) IPGTT (19-week-old HFHS-fed mice, 2 g/kg i.p., n = 5–6). (b) ITT (20-week-old HFHS-fed mice, 0.75 U/kg i.p., n = 5–6). (c) Percentage of β-cell area over total pancreatic area and histogram for β-cell area per islet. (d) Percentage of Ki-67 positive β-cells (f/f, NC: 16 positive cells among 4760 β-cells, KO, NC: 7 positive cells among 3710 β-cells, f/f, HFHS: 46 positive cells among 15005 β-cells, KO, HFHS: 15 positive cells among 7824 β-cells). (e) Percentage of TUNEL positive β-cells. 26-week-old mice, n = 5 for normal chow (NC), n = 6–8 for HFHS (c–e), *P < 0.05. N.D. not detected.