Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Oct 12;7:13026. doi: 10.1038/s41598-017-13432-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

TFG depleted β-cells display smaller insulin crystals and mild ER stress. (a) Representative electron microscopic images of β-cells from 10-week-old f/f and KO mice (scale bars: 2 μm). (b) Insulin crystal diameter inside the granules (f/f: n = 377, KO: n = 435). (c) Islet insulin content (19-week-old mice, n = 8) (left: ng/islet, right: adjusted by the protein concentration). (d) Dilatation of the ER lumen observed in TFG KO β-cell (scale bar: 1 μm). White arrowheads indicate dilated rough ERs. (e) mRNA levels of ER-stress markers in isolated islets (10-week-old mice, n = 6). (f) Glucose-induced insulin secretion from isolated islets treated with or without a chemical chaperone (4-PBA) (20-week-old mice, n = 3–5). The ratio of insulin secretion from KO islets to that from f/f islets is shown in the right panel. *P < 0.05, **P < 0.01, ***P < 0.001.