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. 2017 Oct 12;7:13026. doi: 10.1038/s41598-017-13432-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Microarray analysis revealed downregulation of the Nrf2 pathway in islets of TFG KO mice. Total RNA extracted from isolated islets of 10-week-old f/f and KO mice were subjected to microarray analysis. (a) Gene Ontology (GO) analysis. Top 20 GO terms significantly associated with 97 genes, extracted as described above, are shown. GO terms to which Nrf related genes (56 genes) are annotated with statistical significance (P < 0.05) are shown in red. (b) Transcriptional factors associated with expressions of genes which showed altered expression levels, differing by more than 1.25-fold between f/f and KO islets with statistical significance (P < 0.05), were analyzed using Keymolnet Lite software. Nrf was the only transcriptional factor identified in the analysis. (c) Heat map presentation of genes regulated by Nrf. (d) mRNA levels of genes in the Keap1-Nrf2 pathway in isolated islets (10-week-old mice, n = 6).