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. 2017 Oct 12;7:13066. doi: 10.1038/s41598-017-13577-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SERS effects at different locations of the substrate and the surface profile of the substrate. (a) Representative optical microscope image showing the four regions on the substrate for SERS measurement. (b) The intensities of the characteristic Raman peak of adenine at 734 cm⁻¹ measured in the four regions shown in (a) (n = 10 per region). Error bars, SD. (c) Surface profile of the substrate measured along the white dashed line in (a) using a profiler.