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. 2017 Oct 12;7:13090. doi: 10.1038/s41598-017-12998-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ncr1^cre Ncr1^OE improved control of influenza in vitro and in vivo. (A) Isolated NK cells were sorted for GFP and incubated with the indicated targets at 1:1 ratio. CD107a degranulation was assessed. The experiment was conducted three times, including 15 mice. The figure shows one representative experiment. Values are shown as mean ± SD. *P < 0.05. (B) Ncr1^cre Ncr1^OE TGs were infected with influenza virus (1:500). Lungs were harvested at day 5 post infection and viral titer was quantified. 10 littermates and 8 Ncr1^cre Ncr1^OE TGs were used. Values are shown as mean ± SEM. *P < 0.05. (C,D) Littermates and Ncr1^cre Ncr1^OE TGs were infected with two doses of PR8 influenza and weight loss was monitored daily. The figure is representative of three independent experiments including 15 transgenic mice and at least 15 littermates.