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. 2017 Oct 12;7:13090. doi: 10.1038/s41598-017-12998-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ncr1^cre Ncr1^OE improved control of tumors and metastases in vitro and in vivo. (A) Isolated NK cells were sorted for GFP and incubated with the indicated targets at 1:1 ratio. CD107a degranulation was assessed using flow cytometry. The experiment was conducted three times, including 15 mice. The figure shows one representative experiment. Values are shown as mean ± SD. *P < 0.05. (B,C) Littermates and Ncr1^cre Ncr1^OE TGs were inoculated with B16 cells to the flank, and tumor growth was monitored daily (B). Peritoneal metastases were assessed within each animal when tumors reached endpoint volumes (1000 mm³) and no later than day 14 post tumor inoculation (C). The figure is representative of three independent experiments including 15 transgenic mice and at least 15 littermates.