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. 2017 Oct 12;7:13021. doi: 10.1038/s41598-017-13398-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of ABHD5 silencing on the migration and invasion of LNCaP cells. (A) Expression level of ABHD5, E-Cadherin, Snail and β-actin proteins in shControl and shABHD5 cells. (B) Enhanced cell scattering of shABHD5 cells. shControl and shABHD5 cells were seeded at low density and grown for 2 weeks. Cell colonies (>100 cells/colony) were analyzed under the microscope and sorted into the following groups according to morphology: gathered (G), cells attached to each other tightly; scattered (S), cells scattered but attached loosely; highly scattered (HS), cells detached from each other. Percentages of colonies from each group are plotted in the left panel. Data are presented as mean ± SEM (n = 3) of experiments performed in triplicate. Two-tailed t-test, ***P < 0.001. Representative images of cell colonies are shown on the right. (C) Enhanced cell invasion of shABHD5 cells. A representative image of Transwell invasion assay is shown for each group, respectively, (left panels). Numbers of invasive cell are plotted on the right. Data are presented as mean ± SEM (n = 3) of experiments performed in triplicate. Two-tailed t-test, **P < 0.01.