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. 2017 Sep 21;595(20):6443–6462. doi: 10.1113/JP274380

Figure 11. Model depicting Kindlin‐2 connecting VE‐cadherin/catenin complexes to actin filaments and stabilizing AJs.

Figure 11

VE‐cadherin cytoplasmic tail binds to β‐ or γ‐catenin. Kindlin‐2 has the capacity to directly and simultaneously interact with β‐catenin or γ‐catenin and actin fibres bridging AJs to actin cytoskeleton. This linking function of Kindlin‐2 can also be indirect because Kindlin‐2 may also support and facilitate the interaction of β‐catenin with α‐catenin, the actin‐binding catenin. Altogether, Kindlin‐2 plays an important role in connecting VE‐cadherin/catenin complex to actin filaments, thereby not only stabilizing AJs, but also with respect to contributing to their remodelling.