Figure 5.

Impact of specific maturational processes on the sparsification process. We measured the change in network behavior when, virtually, we only mature a single parameter or small sets of similar parameters from P10 to P20. This enables us to indicate key parameters required for sparsification. (a) The plotted values of $rati{o}_{PS}$ measure the modification-induced changes in $P{S}_{\mathrm{net}}^{\mathrm{amp}}$, i.e. the size of simulated cluster activity, relative to the decrease when transitioning from P10 to P20. The dashed orange line at $rati{o}_{PS}=-100\%$ indicates the normal amount of decrease in $P{S}_{\mathrm{net}}^{\mathrm{amp}}$, as expected when transitioning from P10 to P20. (b) The plotted values of $rati{o}_{AOD}$ measure the modification-induced change in $AO{D}_{\mathrm{ISN}/\mathrm{Unstable}}$, i.e. the ratio of areas of ISN and unstable FP-domains, relative to the increase when transitioning from P10 to P20. The dashed orange line at $rati{o}_{AOD}=+100\%$ indicates the normal amount of increase in AOD _ISN/Unstable, as expected when transitioning from P10 to P20. See Methods for the formulas of $rati{o}_{PS}$ and $rati{o}_{AOD}$. For computing AOD _ISN/Unstable, we considered the E _r-I _r-plane plots with $[E_{\mathrm{r}}^{\max },I_{\mathrm{r}}^{\max }]$ = [10,10] Hz. Parameters combinations are $\mathrm{J}=\left\{J_{\mathrm{E}},J_{\mathrm{I}}\right\}$, ${\mathrm{\tau }}_{\mathrm{syn}}=\left\{{\tau }_{\mathrm{E}},{\tau }_{\mathrm{I}}\right\}$, ${\mathrm{STP}}_{\mathrm{all}}=\left\{{\mathrm{STP}}_{\mathrm{E}},{\mathrm{STP}}_{\mathrm{I}}\right\}$, ${\mathrm{STP}}_{\mathrm{E}}=\{U_{\mathrm{E}},{\tau }_{{\mathrm{r}}_{\mathrm{E}}},{\tau }_{{\mathrm{f}}_{\mathrm{E}}}\}$, ${\mathrm{STP}}_{\mathrm{I}}=\{U_{\mathrm{I}},{\tau }_{{\mathrm{r}}_{\mathrm{I}}},{\tau }_{{\mathrm{f}}_{\mathrm{I}}}\}$, $\mathrm{\theta }=\left\{{\theta }_{\mathrm{E}},{\theta }_{\mathrm{I}}\right\}$.